Engineering of Viruses and Pathogens for Gain-of-Function Research Viral gain-of-function

Main Article Content

Sohail Rao
Manish Singh

Keywords

ethics, laboratory, pathogens, influenza, NIAID

Abstract

No abstract required for a commentary

Abstract 250 | PDF Downloads 304

References

1. Selgelid, M.J. Gain-of-Function Research: Ethical Analysis. Sci. Eng. Ethics (2016) 22:923-964.
2. Kuo, L., Godeke, G. J., Raamsman, M. J., Masters, P. S., and Rottier, P. J. (2000). "Retargeting of coronavirus by substitution of the spike glycoprotein ectodomain: Crossing the host cell species barrier". Journal of Virology. 74 (3): 1393-406.
3. Imai, M., Watanabe, T., Hatta, M., et al. (2012). "Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets". Nature. 486(7403): 420–428.
4. Zhang, Y., Zhang, Q., Kong, H., et al. (2013). "H5N1 Hybrid Viruses Bearing 2009/H1N1 Virus Genes Transmit in Guinea Pigs by Respiratory Droplet". Science. 340 (6139): 1459-1463.
5. World Health Organization Coronavirus (COVID-19) Dashboard. Accessed June 08, 2021; 11:53 a.m. Central European Summer Time. https://covid19.who.int/
6. Watkins, M. Rand Paul and Anthony Fauci Argue Over Theories About COVID-19’s Origin. USA Today. 2021 May 11. https://news.yahoo.com/rand-paul-anthony-fauci-argue-190133625.html
7. U.S Center for Disease Control and Prevention COVID-19 Dashboard. Accessed June 08, 2021; 09:22 a.m. Central Standard Time. https://covid.cdc.gov/covid-data-tracker/#datatracker-home
8. Martin Enserink. Controversial Studies Give a Deadly Flu Virus Wings. Science 02 Dec 2011:Vol. 334, Issue 6060, pp. 1192-1193
9. Pavia, A.T. Laboratory Creation of a Highly Transmissible H5N1 Influenza Virus: Balancing Substantial Risks and Real Benefits. Ann Int Med. 2012 March 20; 156(2): 463-465.
10. News Media Branch. Press Statement on the NSABB Review of H5N1 Research. NIH Office of the Director. 2011 Dec 20. https://www.nih.gov/news-events/news-releases/press-statement-nsabb-review-h5n1-research
11. Kaiser, J. Lab Incidents Lead to Safety Crackdown at CDC. Science: News. 2014 July 13. https://www.sciencemag.org/news/2014/07/lab-incidents-lead-safety-crackdown-cdc
12. U.S. Government Gain-of-Function Deliberative Process and Research Funding Pause on Selected Gain-of-Function Research Involving Influenza, MERS, and SARS Viruses. https://www.phe.gov/s3/dualuse/Documents/gain-of-function.pdf
13. Recommendations for the Evaluation and Oversight of Proposed Gain-of-Function Research. 2016. https://web.archive.org/web/20170107112313/https://osp.od.nih.gov/sites/default/files/resources/NSABB_Final_Report_Recommendations_Evaluation_Oversight_Proposed_Gain_of_Function_Research.pdf
14. Recommended Policy Guidance for Departmental Development of Review Mechanisms for Potential Pandemic Pathogen Care and Oversight. 2017 Jan 9. https://www.phe.gov/s3/dualuse/Documents/P3CO-FinalGuidanceStatement.pdf
15. Collins, F.S. NIH Lifts Funding Pause on Gain-of-Function Research. 2017. The NIH Director. 2017 Dec 19. https://www.nih.gov/about-nih/who-we-are/nih-director/statements/nih-lifts-funding-pause-gain-function-research.
16. Branswell, H. NIH awards $7.5 million grant to EcoHealth Alliance, months after uproar over political interference. STAT: In the Lab. 2020 Aug 27. https://www.statnews.com/2020/08/27/nih-awards-grant-to-ecohealth-alliance-months-after-uproar-over-political-interference/

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