Physiological Effects of Melatonin in Pediatric Population
Main Article Content
Keywords
Melatonin, Adolescents, Pulmonary Hypertension, Valvular Heart Disease, Sexual Maturation
Abstract
N/A
References
Melatonin. (n.d.). Mayo Clinic. Retrieved July 29, 2022, from https://www.mayoclinic.org/drugs-supplements-melatonin/art-20363071
2. National Center for Biotechnology Information (2022). PubChem Compound Summary for CID 896, Melatonin. Retrieved August 1, 2022 from https://pubchem.ncbi.nlm.nih.gov/compound/Melatonin.
3. Melatonin and Sleep. (2022, April 8). Sleep Foundation. Retrieved July 29, 2022, from https://www.sleepfoundation.org/melatonin
4. What Is Melatonin? - Can't Sleep | familydoctor.org. (2000, September 1). FamilyDoctor.org. Retrieved August 1, 2022, from https://familydoctor.org/melatonin/
5. Lelak, K. (2022, June 2). Pediatric Melatonin Ingestions — United States. . . Centers for Disease Control and Prevention, from https://www.cdc.gov/mmwr/volumes/71/wr/mm7122a1.htm 6. Grigg-Damberger, M. M., & Ianakieva, D. (2017). Poor Quality Control of Over-the-Counter Melatonin: What They Say Is Often Not What You Get. Journal of clinical sleep medicine: JCSM : official publication of the American Academy of Sleep Medicine, 13(2), 163–165. https://doi.org/10.5664/jcsm.6434 7. Encyclopædia Britannica. (n.d.). Melatonin. Britannica Academic. Retrieved August 1, 2022, from https://academic-eb-com.ezproxy.southtexascollege.edu/levels/collegiate/article/melatonin/51873 8. MELATONIN: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews. (2005). WebMD. Retrieved August 2, 2022, from https://www.webmd.com/vitamins/ai/ingredientmono-940/melatonin#:%7E:text=People%20most%20 commonly%20use%20 melatonin, support%20best%20of%20these%20 uses 9. Melatonin: What You Need to know. (n.d.). National Center for Complementary and Integrative Health. Retrieved August 1, 2022, from https://www.nccih.nih.gov/health/melatonin-what-you-need-to-know 10. Hardeland R. (2012). Neurobiology, pathophysiology, and treatment of melatonin deficiency and dysfunction. TheScientificWorldJournal, 2012, 640389. https://doi.org/10.1100/2012/640389 11. Procaccini, D. E., & Kudchadkar, S. R. (2021). Melatonin Administration Patterns for Pediatric Inpatients in a Tertiary Children's Hospital. Hospital pediatrics,
Lara, et al Melatonin in Children
https://doi.org/10.47488/dhrp.v2iS2.70
DHR Proceedings ǀ http://dhrproceedings.org 66 2022, Vol. 2 No. S2 62-67
11(11), e308–e312. https://doi.org/10.1542/hpeds.2021-006117 12. What Are the Dangers of Taking Too Much Melatonin? (2022, April 12). Verywell Health. Retrieved August 3, 2022, from https://www.verywellhealth.com/melatonin-overdose-5219376
13. https://www.mayoclinic.org/drugs-supplements-melatonin/art-20363071#:~:text=Less%20 common%20 melatonin%20side%20effects,hours%20of%20making%20the%20 supplement 14. Xie, Z., Chen, F., Li, W. A., Geng, X., Li, C., Meng, X., Feng, Y., Liu, W., & Yu, F. (2017). A review of sleep disorders and melatonin. Neurological research, 39(6), 559–565. https://doi.org/10.1080/01616412.2017.1315864 15. Cai, Z., Klein, T., Geenen, L. W., Tu, L., Tian, S., van den Bosch, A. E., de Rijke, Y. B., Reiss, I., Boersma, E., Duncker, D. J., Boomars, K. A., Guignabert, C., & Merkus, D. (2020). Lower Plasma Melatonin Levels Predict Worse Long-Term Survival in Pulmonary Arterial Hypertension. Journal of clinical medicine, 9(5), 1248. https://doi.org/10.3390/jcm9051248 16. Pulmonary Hypertension in Children. (n.d.). Johns Hopkins Medicine. Retrieved August 1, 2022, from https://www.hopkinsmedicine.org/health/conditions-and-diseases/high-blood-pressure-hypertension/pulmonary-hypertension-in-children
17. Pulmonary hypertension - Symptoms and causes. (2022, April 13). Mayo Clinic. Retrieved August 1, 2022, from https://www.mayoclinic.org/diseases-conditions/pulmonary-hypertension/symptoms-causes/syc-20350697 18. Li SJ, Cheng WL, Kao YH, Chung CC, Trang NN, Chen YJ. Melatonin Inhibits NF-κB/CREB/Runx2 Signaling and Alleviates Aortic Valve Calcification. Front Cardiovasc Med. 2022 Jun 20;9:885293. doi: 10. .2022.885293. PMID: 35795373; PMCID: PMC9251177 https://pubmed.ncbi.nlm.nih.gov/35795373/ 19. Shah SY, Higgins A, Desai MY. Bicuspid aortic valve: Basics and beyond. Cleve Clin J Med. 2018 Oct;85(10):779-784. doi: 10.3949/ccjm.85a.17069. PMID: 30289756. https://pubmed.ncbi.nlm.nih.gov/30289756
20. Greendale, G. A., Witt-Enderby, P., Karlamangla, A. S., Munmun, F., Crawford, S., Huang, M., & Santoro, N. (2020). Melatonin Patterns and Levels During the Human Menstrual Cycle and After Menopause. Journal of the Endocrine Society, 4(11), bvaa115. https://doi.org/10.1210/jendso/bvaa115
21. Boafo, A., Greenham, S., Alenezi, S., Robillard, R., Pajer, K., Tavakoli, P., & de Koninck, J. (2019).
22. Marques P, Skorupskaite K, Rozario KS, et al. Physiology of GnRH and Gonadotropin Secretion. [Updated 2022 Jan 5]. In: Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK279070/
23. Melatonin Information. (n.d.). Mount Sinai. Retrieved August 3, 2022, from https://www.mountsinai.org/health-library/supplement/melatonin 24. Espino, J., Pariente, J. A., & Rodríguez, A. B. (2011). Role of melatonin on diabetes-related metabolic disorders. World journal of diabetes, 2(6), 82–91. https://doi.org/10.4239/wjd.v2.i6.82 25. Garaulet, M., Qian, J., Florez, J. C., Arendt, J., Saxena, R., & Scheer, F. (2020). Melatonin Effects on Glucose Metabolism: Time To Unlock the Controversy. Trends in endocrinology and metabolism: TEM, 31(3), 192–204. https://doi.org/10.1016/j.tem.2019.11.011
26. Type 2 diabetes - Understanding medicine. (n.d.). NHS. Retrieved August 2, 2022, from https://www.nhs.uk/conditions/type-2-diabetes/understanding-medication/
27. Gavin, M. L. (n.d.). What Is Type 2 Diabetes? (for Teens) - Nemours KidsHealth. Kids Health. Retrieved August 2, 2022, from https://kidshealth.org/en/teens/type2.html
28. Does Evidence Exist to Blunt Inflammatory Response by Nutraceutical Supplementation during COVID-19 Pandemic? An Overview
Lara, et al Melatonin in Children
https://doi.org/10.47488/dhrp.v2iS2.70
DHR Proceedings ǀ http://dhrproceedings.org 67 2022, Vol. 2 No. S2 62-67
of Systematic Reviews of Vitamin D, Vitamin C, Melatonin, and Zinc. (2021, April 12). NCBI. Retrieved August 3, 2022, from https://www.ncbi.
2. National Center for Biotechnology Information (2022). PubChem Compound Summary for CID 896, Melatonin. Retrieved August 1, 2022 from https://pubchem.ncbi.nlm.nih.gov/compound/Melatonin.
3. Melatonin and Sleep. (2022, April 8). Sleep Foundation. Retrieved July 29, 2022, from https://www.sleepfoundation.org/melatonin
4. What Is Melatonin? - Can't Sleep | familydoctor.org. (2000, September 1). FamilyDoctor.org. Retrieved August 1, 2022, from https://familydoctor.org/melatonin/
5. Lelak, K. (2022, June 2). Pediatric Melatonin Ingestions — United States. . . Centers for Disease Control and Prevention, from https://www.cdc.gov/mmwr/volumes/71/wr/mm7122a1.htm 6. Grigg-Damberger, M. M., & Ianakieva, D. (2017). Poor Quality Control of Over-the-Counter Melatonin: What They Say Is Often Not What You Get. Journal of clinical sleep medicine: JCSM : official publication of the American Academy of Sleep Medicine, 13(2), 163–165. https://doi.org/10.5664/jcsm.6434 7. Encyclopædia Britannica. (n.d.). Melatonin. Britannica Academic. Retrieved August 1, 2022, from https://academic-eb-com.ezproxy.southtexascollege.edu/levels/collegiate/article/melatonin/51873 8. MELATONIN: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews. (2005). WebMD. Retrieved August 2, 2022, from https://www.webmd.com/vitamins/ai/ingredientmono-940/melatonin#:%7E:text=People%20most%20 commonly%20use%20 melatonin, support%20best%20of%20these%20 uses 9. Melatonin: What You Need to know. (n.d.). National Center for Complementary and Integrative Health. Retrieved August 1, 2022, from https://www.nccih.nih.gov/health/melatonin-what-you-need-to-know 10. Hardeland R. (2012). Neurobiology, pathophysiology, and treatment of melatonin deficiency and dysfunction. TheScientificWorldJournal, 2012, 640389. https://doi.org/10.1100/2012/640389 11. Procaccini, D. E., & Kudchadkar, S. R. (2021). Melatonin Administration Patterns for Pediatric Inpatients in a Tertiary Children's Hospital. Hospital pediatrics,
Lara, et al Melatonin in Children
https://doi.org/10.47488/dhrp.v2iS2.70
DHR Proceedings ǀ http://dhrproceedings.org 66 2022, Vol. 2 No. S2 62-67
11(11), e308–e312. https://doi.org/10.1542/hpeds.2021-006117 12. What Are the Dangers of Taking Too Much Melatonin? (2022, April 12). Verywell Health. Retrieved August 3, 2022, from https://www.verywellhealth.com/melatonin-overdose-5219376
13. https://www.mayoclinic.org/drugs-supplements-melatonin/art-20363071#:~:text=Less%20 common%20 melatonin%20side%20effects,hours%20of%20making%20the%20 supplement 14. Xie, Z., Chen, F., Li, W. A., Geng, X., Li, C., Meng, X., Feng, Y., Liu, W., & Yu, F. (2017). A review of sleep disorders and melatonin. Neurological research, 39(6), 559–565. https://doi.org/10.1080/01616412.2017.1315864 15. Cai, Z., Klein, T., Geenen, L. W., Tu, L., Tian, S., van den Bosch, A. E., de Rijke, Y. B., Reiss, I., Boersma, E., Duncker, D. J., Boomars, K. A., Guignabert, C., & Merkus, D. (2020). Lower Plasma Melatonin Levels Predict Worse Long-Term Survival in Pulmonary Arterial Hypertension. Journal of clinical medicine, 9(5), 1248. https://doi.org/10.3390/jcm9051248 16. Pulmonary Hypertension in Children. (n.d.). Johns Hopkins Medicine. Retrieved August 1, 2022, from https://www.hopkinsmedicine.org/health/conditions-and-diseases/high-blood-pressure-hypertension/pulmonary-hypertension-in-children
17. Pulmonary hypertension - Symptoms and causes. (2022, April 13). Mayo Clinic. Retrieved August 1, 2022, from https://www.mayoclinic.org/diseases-conditions/pulmonary-hypertension/symptoms-causes/syc-20350697 18. Li SJ, Cheng WL, Kao YH, Chung CC, Trang NN, Chen YJ. Melatonin Inhibits NF-κB/CREB/Runx2 Signaling and Alleviates Aortic Valve Calcification. Front Cardiovasc Med. 2022 Jun 20;9:885293. doi: 10. .2022.885293. PMID: 35795373; PMCID: PMC9251177 https://pubmed.ncbi.nlm.nih.gov/35795373/ 19. Shah SY, Higgins A, Desai MY. Bicuspid aortic valve: Basics and beyond. Cleve Clin J Med. 2018 Oct;85(10):779-784. doi: 10.3949/ccjm.85a.17069. PMID: 30289756. https://pubmed.ncbi.nlm.nih.gov/30289756
20. Greendale, G. A., Witt-Enderby, P., Karlamangla, A. S., Munmun, F., Crawford, S., Huang, M., & Santoro, N. (2020). Melatonin Patterns and Levels During the Human Menstrual Cycle and After Menopause. Journal of the Endocrine Society, 4(11), bvaa115. https://doi.org/10.1210/jendso/bvaa115
21. Boafo, A., Greenham, S., Alenezi, S., Robillard, R., Pajer, K., Tavakoli, P., & de Koninck, J. (2019).
Could long-term administration of melatonin to prepubertal children affect timing of puberty? A clinician’s perspective
Nature and Science of Sleep, Volume 11, 1–10. https://doi.org/10.2147/nss.s18136522. Marques P, Skorupskaite K, Rozario KS, et al. Physiology of GnRH and Gonadotropin Secretion. [Updated 2022 Jan 5]. In: Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK279070/
23. Melatonin Information. (n.d.). Mount Sinai. Retrieved August 3, 2022, from https://www.mountsinai.org/health-library/supplement/melatonin 24. Espino, J., Pariente, J. A., & Rodríguez, A. B. (2011). Role of melatonin on diabetes-related metabolic disorders. World journal of diabetes, 2(6), 82–91. https://doi.org/10.4239/wjd.v2.i6.82 25. Garaulet, M., Qian, J., Florez, J. C., Arendt, J., Saxena, R., & Scheer, F. (2020). Melatonin Effects on Glucose Metabolism: Time To Unlock the Controversy. Trends in endocrinology and metabolism: TEM, 31(3), 192–204. https://doi.org/10.1016/j.tem.2019.11.011
26. Type 2 diabetes - Understanding medicine. (n.d.). NHS. Retrieved August 2, 2022, from https://www.nhs.uk/conditions/type-2-diabetes/understanding-medication/
27. Gavin, M. L. (n.d.). What Is Type 2 Diabetes? (for Teens) - Nemours KidsHealth. Kids Health. Retrieved August 2, 2022, from https://kidshealth.org/en/teens/type2.html
28. Does Evidence Exist to Blunt Inflammatory Response by Nutraceutical Supplementation during COVID-19 Pandemic? An Overview
Lara, et al Melatonin in Children
https://doi.org/10.47488/dhrp.v2iS2.70
DHR Proceedings ǀ http://dhrproceedings.org 67 2022, Vol. 2 No. S2 62-67
of Systematic Reviews of Vitamin D, Vitamin C, Melatonin, and Zinc. (2021, April 12). NCBI. Retrieved August 3, 2022, from https://www.ncbi.
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Aug 15, 2022
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