Substance Use Disorder in Young Adults Across the United States

Main Article Content

Shreya Patel
Gabriel Martinez
Anahi Bernal
Isabella Garcia
Stephany Tapia
Jocelin Hernandez
Daniel Martinez
Christian Zuniga
Abril Acevedo
Eric Molina

Keywords

Alcohol, Marijuana, Opioid

Abstract

N/A

Abstract 419 | PDF Downloads 203

References

1. Murphy JG, Dennhardt AA. The behavioral economics of young adult substance abuse. Prev Med. 2016;92:24-30. doi:10.1016/j.ypmed.2016.04.022
2. LePine SE, Klemperer EM, West JC, et al. Exploring Definitions of "Addiction" in Adolescents and Young Adults and Correlation with Substance Use Behaviors. Int J Environ Res Public Health. 2022;19(13):8075. Published 2022 Jun 30. doi:10.3390/ijerph19138075
3. Zou Z, Wang H, d'Oleire Uquillas F, Wang X, Ding J, Chen H. Definition of Substance and Non-substance Addiction. Adv Exp Med Biol. 2017;1010:21-41. doi: 10.1007/978-981-10-5562-1_2. PMID: 29098666.
4. Squeglia LM, Fadus MC, McClure EA, Tomko RL, Gray KM. Pharmacological Treatment of Youth Substance Use Disorders. J Child Adolesc Psychopharmacol. 2019 Aug;29(7):559-572. doi: 10.1089/cap.2019.0009. Epub 2019 Apr 22. PMID: 31009234; PMCID: PMC6727439.
5. Santa Maria DM, Narendorf SC, Cross MB. Prevalence and Correlates of Substance Use in Homeless Youth and Young Adults. J Addict Nurs. 2018 Jan/Mar;29(1):23-31. doi: 10.1097/JAN.0000000000000206. PMID: 29505458.
6. Broman CL. The Availability of Substances in Adolescence: Influences in Emerging Adulthood. J Child Adolesc Subst Abuse. 2016;25(5):487-495. doi: 10.1080/1067828X.2015.1103346. Epub 2016 May 26. PMID: 29200806; PMCID: PMC5710832.
7. McLellan AT, Lewis DC, O'Brien CP, Kleber HD. Drug dependence, a chronic medical illness: implications for treatment, insurance, and outcomes evaluation. JAMA. 2000 Oct 4;284(13):1689-95. doi: 10.1001/jama.284.13.1689. PMID: 11015800.
8. McLellan AT, Starrels JL, Tai B, Gordon AJ, Brown R, Ghitza U, Gourevitch M, Stein J, Oros M, Horton T, Lindblad R, McNeely J. Can Substance Use Disorders be Managed
Using the Chronic Care Model? Review and Recommendations from a NIDA Consensus Group. Public Health Rev. 2014 Jan;35(2):http://www.journalindex.net/visit.php?j=6676. doi: 10.1007/BF03391707. PMID: 26568649; PMCID: PMC4643942.
9. Alcover KC, Lyons AJ, Oluwoye O, Muse ID, Kelly ME, McDonell MG. Onset of alcohol use disorder among alcohol initiates by race/ethnicity. Alcohol. 2021;97:13-21. doi:10.1016/j.alcohol.2021.08.002
10. White AM, Hingson RW, Pan IJ, Yi HY. Hospitalizations for alcohol and drug overdoses in young adults ages 18-24 in the United States, 1999-2008: results from the Nationwide Inpatient Sample. J Stud Alcohol Drugs. 2011;72(5):774-786. doi:10.15288/jsad.2011.72.774
11. McHugh RK, Weiss RD. Alcohol Use Disorder and Depressive Disorders. Alcohol Res. 2019;40(1):arcr.v40.1.01. Published 2019 Jan 1. doi:10.35946/arcr.v40.1.01
12. Grant BF, Stinson FS, Dawson DA, et al. Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Arch Gen Psychiatry. 2004;61(8):807-816. doi:10.1001/archpsyc.61.8.807
13. Room R, Ferris J, Laslett AM, Livingston M, Mugavin J, Wilkinson C. The drinker's effect on the social environment: a conceptual framework for studying alcohol's harm to others. Int J Environ Res Public Health. 2010 Apr;7(4):1855-71. doi: 10.3390/ijerph7041855. Epub 2010 Apr 21. PMID: 20617064; PMCID: PMC2872341.
14. Room R, Jernigan D, Carlini Cotrim B, Gureje O, Mäkelä K, Marshall M, Medina-Mora ME, Monteiro M, Parry C, Partanen J, Riley L, Saxena S. Alcohol in Developing Societies: A Public Health Approach. Finnish Foundation for Alcohol Studies; Helsinki, Finland: 2002
15. What Is Blood Alcohol Concentration (BAC)? | Vaden Health Services. vaden.stanford.edu. https://vaden.stanford.edu/super/education/alcohol-drug-info/reduce-your-risk/what-blood-alcohol-concentration-bac
16. Blood Alcohol Content (BAC): What It Is & Levels. Cleveland Clinic. https://my.clevelandclinic.org/health/diagnostics/22689-blood-alcohol-content-bac#:~:text=Blood%20alcohol%20level%20(BAC)%2C
17. Marketing Communications: Web // University of Notre Dame. Blood Alcohol Concentration // Rev. James E. McDonald, C.S.C., Center for Student Well-Being // University of Notre Dame. Rev. James E. McDonald, C.S.C., Center for Student Well-Being. Published 2019. https://mcwell.nd.edu/your-well-being/physical-well-being/alcohol/blood-alcohol-concentration/
18. Altura BM, Altura BT. Role of magnesium and calcium in alcohol-induced hypertension and strokes as probed by in vivo television microscopy, digital image microscopy, optical spectroscopy, 31P-NMR, spectroscopy and a unique magnesium ion-selective electrode. Alcohol Clin Exp Res. 1994 Oct;18(5):1057-68. doi: 10.1111/j.1530-0277.1994.tb00082.x. PMID: 7847586.
19. Husain K, Ansari RA, Ferder L. Alcohol-induced hypertension: Mechanism and prevention. World J Cardiol. 2014 May 26;6(5):245-52. doi: 10.4330/wjc.v6.i5.245. PMID: 24891935; PMCID: PMC4038773.
20. Hwang CL, Muchira J, Hibner BA, Phillips SA, Piano MR. Alcohol Consumption: A New Risk Factor for Arterial Stiffness? Cardiovasc Toxicol. 2022 Mar;22(3):236-245. doi: 10.1007/s12012-022-09728-8. Epub 2022 Feb 23. PMID: 35195845; PMCID: PMC8863568.
21. Paquot N. Le métabolisme de l’alcool [The metabolism of alcohol]. Rev Med Liege. 2019 May;74(5-6):265-267. French. PMID: 31206264.
22. Epstein M. Alcohol's impact on kidney function. Alcohol Health Res World. 1997;21(1):84-92. PMID: 15706766; PMCID: PMC6826793.
23. Excessive alcohol use and risks to men’s health. Centers for Disease Control and Prevention. October 31, 2022. Accessed August 2, 2023. https://www.cdc.gov/alcohol/fact-sheets/mens-health.htm#:~:text=Adult%20Men%20Drink%20More%20than,with%2049%25%20of%20adult%20women.&text=Men%20are%20more%20likely%20to%20binge%20drink%20than%20women.
24. Alcover KC, Lyons AJ, Oluwoye O, Muse ID, Kelly ME, McDonell MG. Onset of alcohol use disorder among alcohol initiates
by race/ethnicity. Alcohol. 2021;97:13-21. doi:10.1016/j.alcohol.2021.08.002
25. The National Council on Aging. ncoa.org. Published January 10, 2023. https://ncoa.org/article/american-indians-and-alaska-natives-key-demographics-and-characteristics
26. American Addiction Centers. How Different Cultures Deal with Alcoholism. Alcohol.org. Published January 19, 2023. https://alcohol.org/alcoholism-and-race/
27. Highlights for the 2021 National Survey on Drug Use and Health - SAMHSA. Accessed August 3, 2023. https://www.samhsa.gov/data/sites/default/files/2022-12/2021NSDUHFFRHighlightsRE123022.pdf.
28. CDC. Data and Statistics. CDC. Published June 8, 2021. https://www.cdc.gov/marijuana/data-statistics.htm
29. Ansell EB, Laws HB, Roche MJ, Sinha R. Effects of marijuana use on impulsivity and hostility in daily life. Drug Alcohol Depend. 2015 Mar 1;148:136-42. doi: 10.1016/j.drugalcdep.2014.12.029. Epub 2015 Jan 6. PMID: 25595054; PMCID: PMC4330120.
30. Mental Health | Health Effects | Marijuana | CDC. www.cdc.gov. Published April 22, 2022. https://www.cdc.gov/marijuana/health-effects/mental-health.html#:~:text=Marijuana%20use%20has%20also%20been
31. Volkow ND, Swanson JM, Evins AE, DeLisi LE, Meier MH, Gonzalez R, Bloomfield MA, Curran HV, Baler R. Effects of Cannabis Use on Human Behavior, Including Cognition, Motivation, and Psychosis: A Review. JAMA Psychiatry. 2016 Mar;73(3):292-7. doi: 10.1001/jamapsychiatry.2015.3278. PMID: 26842658.
32. NIDA. 2021, April 19. What are marijuana's effects?. Retrieved from https://nida.nih.gov/publications/research-reports/marijuana/what-are-marijuana-effects
33. Sharma P, Murthy P, Bharath MM. Chemistry, metabolism, and toxicology of cannabis: clinical implications. Iran J Psychiatry. 2012 Fall;7(4):149-56. PMID: 23408483; PMCID: PMC3570572.
34. National Institute on Drug Abuse. Is there a link between marijuana use and psychiatric disorders? National Institute on Drug Abuse. Published 2020. https://nida.nih.gov/publications/research-reports/marijuana/there-link-between-marijuana-use-psychiatric-disorders
35. HALL W, DEGENHARDT L. Cannabis use and the risk of developing a psychotic disorder. World Psychiatry. 2008;7(2):68-71. doi:https://doi.org/10.1002/j.2051-5545.2008.tb00158.x
36. John Hopkins Medicine. Mental Health Disorder Statistics. John Hopkins Medicine. Published 2019. https://www.hopkinsmedicine.org/health/wellness-and-prevention/mental-health-disorder-statistics
37. CDC. Data and Statistics. CDC. Published June 8, 2021. https://www.cdc.gov/marijuana/data-statistics.htm
38. Marijuana and hallucinogen use among young adults reached all-time high in 2021. National Institutes of Health (NIH). Published August 22, 2022. https://www.nih.gov/news-events/news-releases/marijuana-hallucinogen-use-among-young-adults-reached-all-time-high-2021
39. Centers for Disease Control and Prevention. Addiction | Health Effects | Marijuana | CDC. www.cdc.gov. Published September 9, 2021. https://www.cdc.gov/marijuana/health-effects/addiction.html
40. Hasin DS, Saha TD, Kerridge BT, et al. Prevalence of Marijuana Use Disorders in the United States Between 2001-2002 and 2012-2013. JAMA Psychiatry. 2015;72(12):1235. doi:https://doi.org/10.1001/jamapsychiatry.2015.1858
41. Taylor JL, Samet JH. Opioid Use Disorder. Ann Intern Med. 2022;175(1):ITC1-ITC16. doi:10.7326/AITC202201180
42. Sharma B, Bruner A, Barnett G, Fishman M. Opioid Use Disorders. Child Adolesc Psychiatr Clin N Am. 2016;25(3):473-487. doi:10.1016/j.chc.2016.03.002
43. Opioid Basics | CDC’s Response to the Opioid Overdose Epidemic | CDC. www.cdc.gov. Published October 2, 2021. https://www.cdc.gov/opioids/basics/index.html#:~:text=Opioids%20are%20a%20class%20of%20drugs%20used%20to%20reduce%20pain.&text=Common%20types%20are%20oxycodone%20(OxyContin
44. Lyden J, Binswanger IA. The United States opioid epidemic. Seminars in Perinatology. 2019;43(3):123-131.
doi:https://doi.org/10.1053/j.semperi.2019.01.001
45. Kosten TR, George TP. The neurobiology of opioid dependence: implications for treatment. Sci Pract Perspect. 2002;1(1):13-20. doi:10.1151/spp021113
46. Jones CM, McCance-Katz EF. Co-occurring substance use and mental disorders among adults with opioid use disorder. Drug and Alcohol Dependence. 2019;197:78-82. doi:https://doi.org/10.1016/j.drugalcdep.2018.12.030
47. Sullivan MD. Depression Effects on Long-term Prescription Opioid Use, Abuse, and Addiction. Clin J Pain. 2018;34(9):878-884. doi:10.1097/AJP.0000000000000603
48. Bohnert ASB, Ilgen MA. Understanding Links among Opioid Use, Overdose, and Suicide. N Engl J Med. 2019;380(1):71-79. doi:10.1056/NEJMra1802148
49. Support EW and I. VA.gov | Veterans Affairs. www.mirecc.va.gov. Accessed August 3, 2023. https://www.mirecc.va.gov/suicideprevention/documents/CPDD-2020_socialconnection_OUD.
50. Seppala DE. Connectedness & Health: The Science of Social Connection. The Center for Compassion and Altruism Research and Education. Published May 9, 2014. Accessed August 3, 2023. https://ccare.stanford.edu/uncategorized/connectedness-health-the-science-of-social-connection-infographic/#:~:text=People%20low%20in%20social%20connection
51. Hall N, Le L, Majmudar I, Teesson M, Mihalopoulos C. Treatment-seeking behavior among people with opioid use disorder in the high-income countries: A systematic review and meta-analysis. PLoS One. 2021 Oct 15;16(10):e0258620. doi: 10.1371/journal.pone.0258620. PMID: 34653220; PMCID: PMC8519451.
52. Piazza PV, Deroche-Gamonet V. A multistep general theory of transition to addiction. Psychopharmacology (Berl). 2013 Oct;229(3):387-413. doi: 10.1007/s00213-013-3224-4. Epub 2013 Aug 21. PMID: 23963530; PMCID: PMC3767888.
53. Padmanathan P, Forbes H, Redaniel MT, Gunnell D, Lewer D, Moran P, Watson B, Degenhardt L, Hickman M. Self-harm and suicide during and after opioid agonist treatment among primary care patients in England: a cohort study. Lancet Psychiatry. 2022 Feb;9(2):151-159. doi: 10.1016/S2215-0366(21)00392-8. Epub 2021 Dec 15. PMID: 34921800.
54. Volkow N, Benveniste H, McLellan AT. Use and Misuse of Opioids in Chronic Pain. Annu Rev Med. 2018 Jan 29;69:451-465. doi: 10.1146/annurev-med-011817-044739. Epub 2017 Oct 13. PMID: 29029586.
55. Ghelardini C, Di Cesare Mannelli L, Bianchi E. The pharmacological basis of opioids. Clin Cases Miner Bone Metab. 2015 Sep-Dec;12(3):219-21. doi: 10.11138/ccmbm/2015.12.3.219. Epub 2015 Dec 29. PMID: 26811699; PMCID: PMC4708964.
56. Pergolizzi JV Jr, Raffa RB, Rosenblatt MH. Opioid withdrawal symptoms, a consequence of chronic opioid use and opioid use disorder: Current understanding and approaches to management. J Clin Pharm Ther. 2020 Oct;45(5):892-903. doi: 10.1111/jcpt.13114. Epub 2020 Jan 27. PMID: 31986228.
57. Study shows how morphine may contribute to bone loss and cancer-induced bone pain. UArizona Health Sciences. Published July 5, 2023. Accessed August 2, 2023. https://healthsciences.arizona.edu/newsroom/news-releases/0723/study-shows-how-morphine-may-contribute-bone-loss-and-cancer-induced#:~:text=Prior%20research%20in%20preclinical%20and
58. Tabanelli R, Brogi S, Calderone V. Targeting Opioid Receptors in Addiction and Drug Withdrawal: Where Are We Going? Int J Mol Sci. 2023 June 29;24(13):10888. doi: 10.3390/ijms241310888. PMID: 37446064; PMCID: PMC10341731.
59. Candiotti KA, Gitlin MC. Review of the effect of opioid-related side effects on the undertreatment of moderate to severe chronic non-cancer pain: tapentadol, a step toward a solution? Curr Med Res Opin. 2010 Jul;26(7):1677-84. doi: 10.1185/03007995.2010.483941. PMID: 20465361.
60. Strang J, Volkow ND, Degenhardt L, Hickman M, Johnson K, Koob GF, Marshall BDL, Tyndall M, Walsh SL. Opioid use disorder. Nat Rev Dis Primers. 2020 Jan 9;6(1):3. doi: 10.1038/s41572-019-0137-5. PMID: 31919349.
61. NIDA. Prescription Opioids DrugFacts. National Institute on Drug Abuse website. https://nida.nih.gov/publications/drugfacts/p
rescription-opioids. June 1, 2021 Accessed August 1, 2023.
62. Mehta N, O'Connell K, Giambrone GP, Baqai A, Diwan S. Efficacy of methylnaltrexone for the treatment of opioid-induced constipation: a meta-analysis and systematic review. Postgrad Med. 2016;128(3):282-9. doi: 10.1080/00325481.2016.1149017. Epub 2016 Feb 23. PMID: 26839023.
63. Hudgins JD, Porter JJ, Monuteaux MC, Bourgeois FT. Prescription opioid use and misuse among adolescents and young adults in the United States: A national survey study. PLoS Med. 2019;16(11):e1002922. Published 2019 Nov 5. doi:10.1371/journal.pmed.1002922
64. Harrison TK, Kornfeld H, Aggarwal AK, Lembke A. Perioperative Considerations for the Patient with Opioid Use Disorder on Buprenorphine, Methadone, or Naltrexone Maintenance Therapy. Anesthesiol Clin. 2018;36(3):345-359. doi:10.1016/j.anclin.2018.04.002
65. SAMHSA. Medications, Counseling, and Related Conditions. www.samhsa.gov. Published March 22, 2023. https://www.samhsa.gov/medications-substance-use-disorders/medications-counseling-related-conditions
66. NIDA. Available Treatments for Marijuana Use Disorders. National Institute on Drug Abuse website. https://nida.nih.gov/publications/research-reports/marijuana/available-treatments-marijuana-use-disorders. April 13, 2021 Accessed August 3, 2023.
67. Griffin KW, Botvin GJ. Evidence-Based Interventions for Preventing Substance Use Disorders in Adolescents. Child and Adolescent Psychiatric Clinics of North America. 2010;19(3):505-526. doi:https://doi.org/10.1016/j.chc.2010.03.005
68. Moreland AD, Lopez CM, Gilmore AK, et al. Substance Use Prevention Programming for Adolescents and Young Adults: A Mixed-Method Examination of Substance Use Perceptions and Use of Prevention Services [published correction appears in Subst Use Misuse. 2021;56(1):174]. Subst Use Misuse. 2020;55(14):2341-2347. doi:10.1080/10826084.2020.1817079
69. Youth.gov. “Prevention | Youth.gov.” Youth.gov, 2019, youth.gov/youth-topics/substance-abuse/evidence-based-programs-youth-substance-abuse-prevention-and-treatment.
70. SAMHSA. Risk and Protective Factors.;2019:1. https://www.samhsa.gov/sites/default/files/20190718-samhsa-risk-protective-factors.pdf
71. Nawi AM, Ismail R, Ibrahim F, et al. Risk and protective factors of drug abuse among adolescents: a systematic review. BMC Public Health. 2021;21(1):2088. Published 2021 Nov 13. doi:10.1186/s12889-021-11906-2