Adverse Effects of Red 40 in PepsiCo Products on Neurodevelopmental Health in Low-Income Hispanic Communities Near the Texas-Mexico Border

Main Article Content

Marisol Acosta

Keywords

Red40, Neurodevelopment, Food Additives, PepsiCo products, Low-income Hispanic Communities, Texas-Mexico Border, Ultra-processed foods, Food insecurity, Health disparities, Enviromental Exposures

Abstract

This literature review explores the potential adverse effects of Red 40, a synthetic food dye commonly found in PepsiCo products, on neurodevelopmental health within low-income Hispanic communities near the Texas-Mexico border. The review synthesizes existing research on Red 40's potential neurotoxic effects, dietary habits, and broader health disparities faced by this population. Factors such as high consumption of ultra-processed foods, food insecurity, and limited access to healthy options may contribute to increased exposure to Red 40, potentially exacerbating neurodevelopmental risks. While direct causal links between Red 40 consumption and neurodevelopmental outcomes in this population are currently lacking, the review highlights significant research gaps and calls for further epidemiological studies, mechanistic investigations, and community-engaged research to better understand the interplay of dietary exposures and social determinants of health. Addressing these challenges requires a holistic, culturally sensitive approach to improve health equity and reduce the burden of dietary-related neurodevelopmental risks in vulnerable communities.

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References

1. Bradman A, Castorina R, Thilakaratne R, et al. Dietary Exposure to United States Food and Drug Administration-Approved Synthetic Food Colors in Children, Pregnant Women, and Women of Childbearing Age Living in the United States. International Journal of Environmental Research and Public Health. 2022;19(15):9661. doi:https://doi.org/10.3390/ijerph19159661
2. Perkins EJ, To KT, Lindsey St. Mary, et al. Developmental, Behavioral and Transcriptomic Changes in Zebrafish Embryos after Smoke Dye Exposure. Toxics. 2022;10(5):210-210. doi:https://doi.org/10.3390/toxics10050210
3. Sharkey J, Meyer RU, St. John J. Promotora‐academic Partnership to Reduce Nutritional Health Disparities among Mexican‐heritage Families in Texas Border Colonias. The FASEB Journal. 2016;30(S1). doi:https://doi.org/10.1096/fasebj.30.1_supplement.901.11
4. Stein DO, Chakraborty J. Racial, Ethnic, and Socioeconomic Disparities in Exposure to Fast Food in Hillsborough County, Florida. Florida Public Health Review. 2010;7(1):83-92.
5. Monda A, Ida M, Villano I, et al. Ultra-Processed Food Intake and Increased Risk of Obesity: a Narrative Review. Foods. 2024;13(16):2627-2627. doi:https://doi.org/10.3390/foods13162627
6. Prescott SL, D’Adamo CR, Holton KF, Ortiz S, Overby N, Logan AC. Beyond Plants: the Ultra-Processing of Global Diets Is Harming the Health of People, Places, and Planet. International Journal of Environmental Research and Public Health. 2023;20(15):6461. doi:https://doi.org/10.3390/ijerph20156461
7. Marks AB. Taming America’s Sugar Rush: a Traffic-Light Label Approach. SSRN Electronic Journal. 2020;62(683). doi:https://doi.org/10.2139/ssrn.3731112
8. Apergi K, Malisova O, Vlassopoulos A, Fidanoglou P, Kandyliari A, Kapsokefalou M. Investigating the Sociodemographic and Health Characteristics of Non-Sugar Sweeteners Consumption in Greek School-Aged Children: a Cross-Sectional Study. Children. 2024;11(7):813. doi:https://doi.org/10.3390/children11070813
9. Hem-Lee-Forsyth S, Sandoval B, Bryant H. A Tridimensional View of the Hispanic Health Paradox: Its Relationship with faith, the Enclave theory, and Familism. Advances in Social Sciences Research Journal. 2021;8(12):317-345. doi:https://doi.org/10.14738/assrj.812.11476
10. Kronenfeld JP, Graves KD, Penedo FJ, Yanez B. Overcoming Disparities in Cancer: a Need for Meaningful Reform for Hispanic and Latino Cancer Survivors. The Oncologist. 2021;26(6):443-452. doi:https://doi.org/10.1002/onco.13729
11. Mota-Bertran A, Coenders G, Plaja P, Saez M, Barceló MA. Air Pollution and Children’s Mental Health in Rural areas: Compositional spatio-temporal Model. Scientific Reports. 2024;14(1):1-13. doi:https://doi.org/10.1038/s41598-024-70024-2
12. Larroya A, Pantoja J, Codoñer-Franch P, Cenit MC. Towards Tailored Gut Microbiome-Based and Dietary Interventions for Promoting the Development and Maintenance of a Healthy Brain. Frontiers in Pediatrics. 2021;9. doi:https://doi.org/10.3389/fped.2021.705859
13. Berding K, Vlckova K, Marx W, et al. Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health. Advances in Nutrition. 2021;12(4). doi:https://doi.org/10.1093/advances/nmaa181
14. Briant KJ, Sanchez J, Galvan A, Gonzalez V, Wu-Georges S, Thompson B. Abstract A35: Eat Healthy, Be Active Community Workshops for a Rural Hispanic Population. Cancer Epidemiology Biomarkers & Prevention. 2017;26(2_Supplement):A35-A35. doi:https://doi.org/10.1158/1538-7755.disp16-a35
15. Andreea Ioana Enache (Bontos, Marius Daniel Bontos, Danut Ionel Vaireanu. A Novel Information System for Studying the Interactions between, Foods, Food Additives and Packaging Materials. Revista De Chimie. 2013;64(10):1139-1142. https://www.researchgate.net/publication/262609981_A_Novel_Information_System_for_Studying_the_Interactions_between_Foods_Food_Additives_and_Packaging_Materials
16. Wheaton AG. Short Sleep Duration among Infants, Children, and Adolescents Aged 4 Months–17 Years — United States, 2016–2018. MMWR Morbidity and Mortality Weekly Report. 2021;70(38). doi:https://doi.org/10.15585/mmwr.mm7038a1
17. Zimmermann LK. Chronotype and the Transition to College Life. Chronobiology International. 2011;28(10):904-910. doi:https://doi.org/10.3109/07420528.2011.618959
18. Mark Lawrence Wong, Nagata JM, Barreto M. Sleep and Socioemotional Outcomes among Sexual and Gender Minority Adolescents: a Longitudinal Study. Archives of sexual behavior. Published online November 22, 2023. doi:https://doi.org/10.1007/s10508-023-02732-1
19. Keuppens L, Marten F, Dieter Baeyens, Boyer B, Danckaerts M, Van. Sleep IntervEntion as Symptom Treatment for ADHD (SIESTA)-Blended CBT Sleep Intervention to Improve sleep, ADHD Symptoms and Related Problems in Adolescents with ADHD: Protocol for a Randomised Controlled Trial. BMJ Open. 2023;13(4):e065355-e065355. doi:https://doi.org/10.1136/bmjopen-2022-065355
20. Kim J, Vander Stoep A, McCauley E. 0394 Differential Role of Sleep Problems on Depression and Suicide in Community Adolescents. Sleep. 2020;43(Supplement_1):A151-A151. doi:https://doi.org/10.1093/sleep/zsaa056.391
21. Shen C, Mireku MO, Martina Di Simplicio, et al. Bidirectional Associations between Sleep Problems and Behavioural Difficulties and Health‐related Quality of Life in adolescents: Evidence from the SCAMP Longitudinal Cohort Study. JCPP Advances. 2022;2(3). doi:https://doi.org/10.1002/jcv2.12098
22. Shen C, Smith RB, Heller J, et al. Depression and Anxiety in Adolescents during the COVID-19 Pandemic in Relation to the Use of Digital Technologies: Longitudinal Cohort Study. Journal of Medical Internet Research. 2024;26(1):e45114. doi:https://doi.org/10.2196/45114
23. McMakin DL, Alfano CA. Sleep and Anxiety in Late Childhood and Early Adolescence. Current Opinion in Psychiatry. 2015;28(6):483-489. doi:https://doi.org/10.1097/YCO.0000000000000204
24. Thapa S, Yadav DK. Role of Sleep Problem on Suicidal Behaviour and non-suicidal self-injury among Adolescents in Pokhara, Nepal. Islam MdS, ed. PLOS ONE. 2024;19(9):e0305221. doi:https://doi.org/10.1371/journal.pone.0305221
25. Chang LY, Chang HY, Lin LN, Wu CC, Yen LL. Transitions in Sleep Problems from Late Adolescence to Young adulthood: a Longitudinal Analysis of the Effects of Peer Victimization. Aggressive Behavior. 2017;44(1):69-82. doi:https://doi.org/10.1002/ab.21725
26. Wolfson AR, Harkins E, Johnson M, Marco C. Effects of the Young Adolescent Sleep Smart Program on Sleep Hygiene practices, Sleep Health efficacy, and Behavioral well-being. Sleep Health. 2015;1(3):197-204. doi:https://doi.org/10.1016/j.sleh.2015.07.002
27. Gupta M, Gupta N, Fradkin Y, Petti T. Sleep Disturbances in Children and Adolescents with Autism Spectrum Disorder: An Overview for Clinicians. Adolescent Psychiatry. 2023;13. doi:https://doi.org/10.2174/2210676613666230126115646
28. Morales-Muñoz I, Durdurak BB, Bilgin A, Marwaha S, Winsper C. Understanding the Relationship between Sleep Problems in Early Childhood and Borderline Personality Disorder: a Narrative Review. Nature and Science of Sleep. 2021;Volume 13:2175-2202. doi:https://doi.org/10.2147/nss.s311672
29. Chattu V, Manzar Md, Kumary S, Burman D, Spence D, Pandi-Perumal S. The Global Problem of Insufficient Sleep and Its Serious Public Health Implications. Healthcare. 2018;7(1):1. doi:https://doi.org/10.3390/healthcare7010001
30. Brenda, Morrissey A, Wu Y, et al. Pica practices, anemia, and Oral Health outcomes: a Systemic Review. BMC Oral Health. 2025;25(1). doi:https://doi.org/10.1186/s12903-024-05371-7
31. Mbou ASM, Djoko GRP, Ketchaji A, et al. Determinants of Anemia in school-going adolescents: a Case Study in Douala, Cameroon. BMC Public Health. 2025;25(1). doi:https://doi.org/10.1186/s12889-024-21224-y
32. Pinto S, Correia-de-Sá T, Sampaio-Maia B, Vasconcelos C, Moreira P, Ferreira-Gomes J. Eating Patterns and Dietary Interventions in ADHD: a Narrative Review. Nutrients. 2022;14(20):4332. doi:https://doi.org/10.3390/nu14204332
33. Holscher HD, Chumpitazi BP, Dahl WJ, et al. Perspective: Assessing Tolerance to Nondigestible Carbohydrate Consumption. Advances in Nutrition. Published online August 30, 2022. doi:https://doi.org/10.1093/advances/nmac091
34. Capra ME, Monopoli D, Stanyevic B, et al. Plant-Based Diets in Pediatric Subjects: Heart-Healthy Option or Dangerous Choice? Healthcare. 2024;12(22):2290. doi:https://doi.org/10.3390/healthcare12222290
35. Bold KW, Kong G, O’Malley SS. The Scientific Basis for the Regulation of Flavors in Tobacco Products. Annual Review of Clinical Psychology. 2024;20(1). doi:https://doi.org/10.1146/annurev-clinpsy-080921-075624
36. Le PN, Adachi Y, Anastasiou E, et al. Global change, Climate change, and Asthma in children: Direct and Indirect Effects - a WAO Pediatric Asthma Committee Report. World Allergy Organization Journal. 2024;17(11):100988-100988. doi:https://doi.org/10.1016/j.waojou.2024.100988
37. Luo YS, Chen Z, Blanchette AD, et al. Relationships between Constituents of Energy Drinks and Beating Parameters in Human Induced Pluripotent Stem Cell (iPSC)-Derived Cardiomyocytes. Food and Chemical Toxicology. 2021;149:111979. doi:https://doi.org/10.1016/j.fct.2021.111979
38. Rahelić V, Perković T, Romić L, et al. The Role of Behavioral Factors on Chronic Diseases—Practice and Knowledge Gaps. Healthcare. 2024;12(24):2520. doi:https://doi.org/10.3390/healthcare12242520
39. Baker BH, Melough MM, Paquette AG, et al. Ultra-processed and Fast Food consumption, Exposure to Phthalates during pregnancy, and Socioeconomic Disparities in Phthalate Exposures. Environment International. 2024;183:108427. doi:https://doi.org/10.1016/j.envint.2024.108427
40. Trumbo PR, Bleiweiss-Sande R, Campbell JK, et al. Toward a science-based Classification of Processed Foods to Support Meaningful Research and Effective Health Policies. Frontiers in Nutrition. 2024;11. doi:https://doi.org/10.3389/fnut.2024.1389601

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